WHAT IS HYPEREOSINOPHILIC SYNDROME (HES)?
Hypereosinophilic syndrome (HES) is a rare disease and defined by persistent hypereosinophilia (>1500 per microliter) and evidence of eosinophil-mediated organ damage or dysfunction.1,2
Potentially fatal disorders associated with HES include1:
THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN HYPEREOSINOPHILIC SYNDROME
Dysregulation of biological mechanisms involved in eosinophil recruitment and activation can lead to end-organ damage due to eosinophil-mediated tissue damage.2
CLINICAL CONSEQUENCES OF HYPEREOSINOPHILIC SYNDROME (HES)
Hypereosinophilic syndrome can manifest as tissue-specific or widespread organ damage, resulting in diverse symptoms. Worsening of clinical features, or flares, can occur during treatment or upon withdrawal.2
Organ involvement in hypereosinophilic syndrome2
*Includes cardiac and vascular involvement.