EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES

Hypereosinophilic syndrome (HES)

Eosinophilic
asthma (EA)

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
esophagitis (EoE)

Eosinophilic granulomatosis with polyangiitis (EGPA)

Hypereosinophilic
syndrome (HES)

WHAT IS HYPEREOSINOPHILIC SYNDROME (HES)?

Hypereosinophilic syndrome (HES) is a rare disease and defined by persistent hypereosinophilia (>1500 per microliter) and evidence of eosinophil-mediated organ damage or dysfunction.1,2

Potentially fatal disorders associated with HES include1:

Potential Fatal Disorders Associated with HES
Potential Fatal Disorders Associated with HES

 

THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN HYPEREOSINOPHILIC SYNDROME

Dysregulation of biological mechanisms involved in eosinophil recruitment and activation can lead to end-organ damage due to eosinophil-mediated tissue damage.2

 

CLINICAL CONSEQUENCES OF HYPEREOSINOPHILIC SYNDROME (HES)

Hypereosinophilic syndrome can manifest as tissue-specific or widespread organ damage, resulting in diverse symptoms. Worsening of clinical features, or flares, can occur during treatment or upon withdrawal.2

Organ involvement in hypereosinophilic syndrome2

Organ Involvement in Hyper-Eosinophilic Syndrome
Organ Involvement in Hyper-Eosinophilic Syndrome

*Includes cardiac and vascular involvement.

ASTRAZENECA IS COMMITTED TO DISCOVERING NEW WAYS TO TREAT EOSINOPHILIC IMMUNE DYSFUNCTION IN HYPEREOSINOPHILIC SYNDROME.