EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES

Eosinophilic esophagitis (EoE)

Eosinophilic
asthma (EA)

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
esophagitis (EoE)

Eosinophilic granulomatosis with polyangiitis (EGPA)

Hypereosinophilic
syndrome (HES)

WHAT IS EOSINOPHILIC ESOPHAGITIS (EoE)?

Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus characterized by eosinophilic inflammation and symptoms related to esophageal dysfunction.1-3

Symptoms associated with eosinophilic esophagitis include1,2:

  • Dysphagia
  • Upper abdominal pain
  • Chest pain
  • Painful swallowing

Incidence4,5

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Person Icon

Approximately 1-20 new cases per
100,000 people per year


Prevalence6

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Percentage Icon

22.7 cases per 100,000
(95% CI 12.4-36.0)

 

THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN EOSINOPHILIC ESOPHAGITIS

Dysregulated immune responses lead to the recruitment and activation of eosinophils, potentially causing eosinophilic inflammation and symptoms associated with esophageal dysfunction.7-9

Role of Eosinophilic Immune Dysfunction in Eosinophilic Esophagitis
Role of Eosinophilic Immune Dysfunction in Eosinophilic Esophagitis

Adapted from O’Shea KM, et al. Gastroenterology. 2018.7

 

IMPACT OF EOSINOPHILIC ESOPHAGITIS ON PATIENTS

Eosinophilic esophagitis is a lifelong, progressive disease that can significantly impact patients’ quality of life.10,11

Impact of Eosinophilic Esophagitis on Patients
Impact of Eosinophilic Esophagitis on Patients

ASTRAZENECA IS COMMITTED TO DISCOVERING NEW WAYS TO TREAT EOSINOPHILIC IMMUNE DYSFUNCTION IN EOSINOPHILIC ESOPHAGITIS.