EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES
Eosinophilic esophagitis (EoE)
Eosinophilic
asthma (EA)
Chronic rhinosinusitis with nasal polyps (CRSwNP)
Eosinophilic
esophagitis (EoE)
Eosinophilic granulomatosis with polyangiitis (EGPA)
Hypereosinophilic
syndrome (HES)
WHAT IS EOSINOPHILIC ESOPHAGITIS (EoE)?
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus characterized by eosinophilic inflammation and symptoms related to esophageal dysfunction.1-3
Symptoms associated with eosinophilic esophagitis include1,2:
- Dysphagia
- Upper abdominal pain
- Chest pain
- Painful swallowing
Incidence4,5
Approximately 1-20 new cases per
100,000 people per year
Prevalence6
22.7 cases per 100,000
(95% CI 12.4-36.0)
THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN EOSINOPHILIC ESOPHAGITIS
Dysregulated immune responses lead to the recruitment and activation of eosinophils, potentially causing eosinophilic inflammation and symptoms associated with esophageal dysfunction.7-9
Adapted from O’Shea KM, et al. Gastroenterology. 2018.7
IMPACT OF EOSINOPHILIC ESOPHAGITIS ON PATIENTS
Eosinophilic esophagitis is a lifelong, progressive disease that can significantly impact patients’ quality of life.10,11
