EOSINOPHILIC IMMUNE DYSFUNCTION
ACROSS INFLAMMATORY DISEASES

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
asthma (EA)

Chronic rhinosinusitis with nasal polyps (CRSwNP)

Eosinophilic
esophagitis (EoE)

Eosinophilic granulomatosis with polyangiitis (EGPA)

Hypereosinophilic
syndrome (HES)

WHAT IS CHRONIC RHINOSINUSITIS WITH NASAL POLYPS (CRSwNP)?

Chronic rhinosinusitis (CRS) is characterized by persistent, symptomatic inflammation of the mucosa of the nose and paranasal sinuses.1

Nasal polyps (NP) are benign inflammatory masses arising from the mucosa of the nose and paranasal sinuses.1

The estimated prevalence of CRSwNP is 2%-7%.2,3

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Approximately
1 in 20

people have CRS4

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Up to 30%
of patients

with CRS have CRSwNP in the US1

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Up to 90%
of CRSwNP

patients have eosinophil-dominant infiltration5

 

THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Eosinophilic inflammation potentially contributes to key pathological mechanisms in chronic rhinosinusitis with nasal polyps.6-10

Role of Eosinophilic Immune Dysfunction in Chronic Rhinosinusitis with Nasal Polyps
Role of Eosinophilic Immune Dysfunction in Chronic Rhinosinusitis with Nasal Polyps

Adapted from Kita and Bochner, in Middleton’s Allergy: Principles and Practice, 8th Edition, 2014.6

ECP=eosinophil cationic protein; EDN=eosinophil-derived neurotoxin; EPX=eosinophil peroxidase; GM-CSF=granulocyte-macrophage colony-stimulating factor; MBP=major basic protein; MMP=matrix metalloproteinase; RANTES=regulated on activation, normal T cells expressed and secreted; TGF=transforming growth factor.

 

CLINICAL CONSEQUENCES OF CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Clinical manifestations of CRSwNP: nasal obstruction, reduction in sense of smell, nasal discharge, sleep disturbance, and adverse effects on quality of life.1,11

Surgery to remove polyps may be required in patients whose symptoms are not controlled with corticosteroids. However, rates of relapse and repeated intervention can be high.1,11

ASTRAZENECA IS COMMITTED TO UNCOVERING THE ROLE OF EOSINOPHILIC IMMUNE DYSFUNCTION IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS.